This clearly qualitatively shows the level of impurity as it is much heavier showing it contains other compounds weighing it down, which it should not have if synthesised meticulously. For the reaction to take place, an inorganic acid such as phosphoric acid is used as a catalyst.
In Table 8, the differentiation of synthesized acetylsalicylic acid from commercially available aspirin was accounted for. An above observation was made when sodium carbonate reacted with 2-hydroxybenzoic acid which was expected due to CO2 being released when an acid and a carbonate combine, below shows the reaction that took place.
During this cooling, each solute molecule in turn approaches a growing crystal and rests on the crystal surface. While waiting for the sample to vacuum dry weigh a weigh boat. Perhaps, the sample was not weighed properly or it was weighed when still wet. Crystallization should begin once the solution reaches room temperature.
Reweigh your sample and record the new mass sample. Swirl the mixture in the Erlenmeyer flask for approximately one minute so that all of its contents have completely dissolved.
Since this esterification reaction is not spontaneous, sulfuric acid was used as a catalyst to initiate the reaction. While heating the mixture, measure out 70 mL of DI water and then put it in a mL beaker. Heating was employed so that salicylic acid would melt and react with acetic anhydride.
Load the capillary tube into the melting point apparatus and begin heating. All mixtures, apart from the pure aspirin, exhibited this although all varied in colour intensity.
Although this level varied and cannot be compared due to the difference in format of the results for each test, it can be seen, in general, that the crude aspirin contained more impurities than the pure aspirin and the willow bark product was the most impure of them all.
After the sample has dried for 5 minutes, turn off the vacuum filtration apparatus and retrieve the purified product from the Buchner funnel and place it in the previously weighed weigh boat. Place the Erlenmeyer flask in an ice bath for 30 minutes. The chilled solution was then filtered through vacuum filtration to isolate the pure crystals.
A high or even moderate yield was not achieved. Check it out https: In a mL Erlenmeyer flask add 5 mL of acetic anhydride, 1. The pure aspirin shows only one spot on the paper, this is because it consists of only one compound, that being 2-acetoxybenzoic acid aspirin.
Check it out https: Percentages of the substances could have been lost or misplaced during stages of the procedure. This shows that commercially available aspirin contains starch. Recrystallisation also loses product and therefore yield as some product may still be left in the solution or on the filter paper.
Montes, Ingrid, et al. Hofmann worked for Bayer, which then named acetylsalicylic acid compound aspirin. This reaction is simplified to: An impure compound will exhibit a lower melting point than this, which is what was observed in both the willow bark product and the crude aspirin.
Once the melting point has been determined turn off the apparatus so it may cool and dispose of your capillary tube in the appropriate waste bin. The yield is calculated to look at how well the reaction has been completed. Before the crude aspirin was recrystallised it may have contained various impurities that were not all eradicated by the precipitation process, these could include: While waiting for those items to cool, set up the vacuum filtration apparatus.
Tap the crystal product down to the bottom of the capillary tube. In this part, purification is not yet complete it was continued on the recrystallization part. Tap the crystal product down to the bottom of the capillary tube. This shows that the oxygen in salicylic acid attacks one of the carbons in acetic anhydride.
The percent yield was May 23, · RESULTS AND DISCUSSION. SUMMARY AND CONCLUSION. Labels: aspirin, aspirin synthesis, CHEM 40, chemistry, full report, Full Report: Synthesis of Aspirin, synthesis, synthesis of aspirin.
8 comments: eizup March 8, at PM. This comment has been removed by the author. Experiment 11 Synthesis and Analysis of Aspirin Part I: Synthesis of Aspirin Caution!
The preparation of aspirin involves the use of two very hazardous materials - concentrated sulfuric Explain why the percent of your aspirin was different from the results obtained from the commercial aspirin. 3. Old aspirin exposed to moisture often. Results and conclusion for aspirin synthesis.
Topics: Aspirin, Furthermore, the other objectives were to enable students to conduct the synthesis of aspirin, reinforce skills or recrystallisation and the technique of melting point determination.
The amount of each compound should be the same because there is a ratio between them. Conclusion Synthesis Of Aspirin Lab. Analysis – Synthesising Aspirin results After recrystallisation differences between the crude and purified aspirin were noted.
The impure (crude) aspirin was powered and fluffy with small clumps and was slightly yellow in colour whereas the pure aspirin has a less fluffy crystalline powder and was whiter. After the synthesis of aspirin, the product was recrystallized for purification to rid the product of impurities.
A major impurity that could be found in the crude product would be unreacted salicylic acid. The crude product and the purified product can be tested using ferric chloride. Results. g of Salicylic acid was obtained after. SYNTHESIS OF ASPIRIN 3.
Do this step in the hood. Place the mL beaker in the mL beaker of warm water (70–80°C). Use a stirring rod to get the reac-tants into solution. Allow the mixture to react for about 5 minutes in the warm water. 4. Remove the mL beaker, and while the.Download